Interesting new paper with @tbkepler and Kelsoe as senior authors:
One of the main points is that for real antigens, GC selection is “permissive”, meaning that a range of affinities for GC B cells is observed:
Particularly interesting for people interested in the effect of molecular substitution on affinity, they reconstruct phylogenetic trees and label them with affinities. We’ve seen this before for HIV BNAbs, but it’s neat to see data for other antigens appearing.
This other recent paper:
also showed “permissive selection” in that certain rather poorly binding clonal lineages were observed at high frequency. [Credit: Trevor Bedford pointed this out during our journal club.]
Definitely some good material here for those working in mathematical models of GCs!