I have a question about TCR rearrangement.
We know TCR VJD rearrangement happens in the thymus development and it’s a “somatic recombination”, dose this means TCR rearrangement only happens during the development stage of embryo development? If so, is it true that the new rearrangement will never happen again after born and the clonotype number of TCR will never increase during a human life? (decrease only?)
If there could be new VDJ recombination happens so the clonotype numbers of T cells could increase in adulthood. Is there any studies show that in what situations make the increasing of clonotype? eg, more exercise? healthy lifestyle? or any medications?