It is not totally clear to me what you mean when you write:[quote=“Peterche, post:2, topic:308”]
PD-1/PDL-1 increases TCR diversity when suppress tumor growth
Maybe you could make it more explicit to me what you mean here?
In general (not only in this case) I hear the word
diversity being thrown around a lot but I rarely find it very informative unless there is a clear definition of what diversity is and how it relates to the repertoire. Increased diversity in a TCR repertoire might as well mean that your are exposed to plenty of bugs (living with animals, having kids etc.), or going the other way around, that you have low diversity because of a recent massive clonal expansion caused by an infection.
The last is what is hoped for when treating with PD-1 inhibitors. In this case T cells recognising tumor specific epitopes are relieved from suppression and will therefore expand to take up a large part of the T cells and then dealing with the tumor. So then succesful PD-1 inhibition would be reflected in a temporarily lower diversity TCR repertoire.